ANGPTL4 (基因名), Angiopoietin-related protein 4 (蛋白名), angl4_bovin.
产品名称:
Bovine ANGPTL4/ Angiopoietin-related protein 4 CLIA Kit
血管生成素相关蛋白4
货号:
U2085b
商标:
EIAab®
监管等级:
别名:
Angiopoietin-like protein 4
检测方法:
CLIA
特异性:
Natural and recombinant bovine Angiopoietin-related protein 4
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cardiovascular
通用注释
亚单元:
Homooligomer. The homooligomer undergoes proteolytic processing to release its carboxyl fibrinogen-like domain, which circulates as a monomer. The homooligomer unprocessed form is able to interact with the extracellular matrix.
功能:
Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.
亚细胞位置:
Secreted
Secreted
Extracellular space
Extracellular matrix
The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4 (By similarity).
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
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