Anxa2 (基因名), Annexin A2 (蛋白名), anxa2_rat.
产品名称:
Rat Anxa2/ Annexin A2 CLIA Kit
膜联蛋白A2
货号:
U1944r
商标:
EIAab®
监管等级:
别名:
Annexin II, Annexin-2, Calpactin I heavy chain, Calpactin-1 heavy chain, Chromobindin-8, Lipocortin II, Placental anticoagulant protein IV, Protein I, p36, PAP-IV, Anx2
检测方法:
CLIA
特异性:
Natural and recombinant rat Annexin A2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Epigenetics
通用注释
亚单元:
Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36 (By similarity). Interacts with ATP1B1 (By similarity). Interacts with DYSF (By similarity). Interacts with COCH. Interacts (via repeat Annexin 1) with PCSK9 (via the C-terminal domain); the interaction inhibits the degradation of LDLR. Interacts with CEACAM1 (via the cytoplasmic domain); this interaction is regulated by phosphorylation of CEACAM1.
功能:
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9.
亚细胞位置:
Secreted
Extracellular space
Extracellular matrix
Basement membrane
Melanosome
In the lamina beneath the plasma membrane.
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