APTX (基因名), Aprataxin (蛋白名), aptx_bovin.
产品名称:
Bovine APTX/ Aprataxin CLIA Kit
Aprataxin
货号:
U9623b
商标:
EIAab®
监管等级:
别名:
Forkhead-associated domain histidine triad-like protein, FHA-HIT
检测方法:
CLIA
特异性:
Natural and recombinant bovine Aprataxin
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Interacts with single-strand break repair proteins XRCC1, XRCC4, ADPRT and p53/TP53. Interacts with NCL. Interacts (via FHA-like domain) with MDC1 (phosphorylated).
功能:
DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH2) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity.
亚细胞位置:
Nucleus
Nucleoplasm
Nucleus
Nucleolus
Upon genotoxic stress, colocalizes with XRCC1 at sites of DNA damage. Colocalizes with MDC1 at sites of DNA double-strand breaks. Interaction with NCL is required for nucleolar localization (By similarity).
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
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