ARID5B (基因名), AT-rich interactive domain-containing protein 5B (蛋白名), ari5b_canlf.
产品名称:
Dog ARID5B/ AT-rich interactive domain-containing protein 5B CLIA Kit
货号:
-
商标:
EIAab®
监管等级:
别名:
ARID domain-containing protein 5B
检测方法:
CLIA
特异性:
Natural and recombinant dog AT-rich interactive domain-containing protein 5B
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
N/A
功能:
Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-337, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation.
亚细胞位置:
Nucleus
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