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ATP2A2 (基因名), Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (蛋白名), at2a2_pig.

产品名称:

Pig ATP2A2/ Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 CLIA Kit
SERCA2

货号:

U12575p

商标:

EIAab^®

监管等级:

RUO

别名:

Calcium pump 2, Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform, Endoplasmic reticulum class 1/2 Ca(2+) ATPase, SERCA2

检测方法:

CLIA

特异性:

Natural and recombinant pig Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Neurosciences

规格 & 价格:

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通用注释

亚单元:

Interacts with sarcolipin (SLN) (By similarity). Interacts with phospholamban (PLN) (By similarity). Interacts with myoregulin (MRLN) (By similarity). Interacts with DWORF (By similarity). Isoform 1 interacts with TRAM2 (via C-terminus). Interacts with HAX1. Interacts with S100A8 and S100A9 (By similarity). Interacts with SLC35G1 and STIM1. Interacts with TMEM203. Interacts with TMEM64 and PDIA3.

功能:

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation.

亚细胞位置:

Endoplasmic reticulum membrane Multi-pass membrane protein Sarcoplasmic reticulum membrane Multi-pass membrane protein

数据库链接

UniGene:

Ssc.97090

KEGG:

ssc:396875

Pfam:

PF00689

Uniprot:

P11607

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