ATP2B1 (基因名), Plasma membrane calcium-transporting ATPase 1 (蛋白名), at2b1_pig.
产品名称:
Pig ATP2B1/ Plasma membrane calcium-transporting ATPase 1 CLIA Kit
质膜钙转运ATP酶1
货号:
U12577p
商标:
EIAab®
监管等级:
别名:
Plasma membrane calcium ATPase isoform 1, Plasma membrane calcium pump isoform 1, PMCA1
检测方法:
CLIA
特异性:
Natural and recombinant pig Plasma membrane calcium-transporting ATPase 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Monomer. Dimer. Oligomer. Calmodulin binding. Interacts with PDZD11. Interacts with SLC35G1 and STIM1. Interacts with YWHAE; interacts with the monomeric and dimeric forms of the YWHAE but prefer the monomer form; this interaction inhibits calcium-transporting ATPase activity (By similarity). Interacts with NPTN; this interaction stabilizes ATP2B1 and increases ATPase activity; this interaction controls T cell calcium homeostasis following T cell activation. Interacts with EPB41; regulates small intestinal calcium absorption through regulation of membrane expression of ATP2B1 (By similarity).
功能:
Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (By similarity). Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (By similarity).
亚细胞位置:
Cell membrane
Multi-pass membrane protein
Basolateral cell membrane
Cell junction
Synapse
Colocalizes with SV2A in photoreceptor synaptic terminals. Colocalizes with NPTN to the immunological synapse. Colocalizes with EPB41 to the basolateral membrane in enterocyte.
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