Mouse Bad/ Bcl2-associated agonist of cell death CLIA Kit
细胞死亡Bcl2拮抗剂

货号:

U15040m

商标:

EIAab^®

监管等级:

RUO

别名:

Bcl-2-binding component 6, Bcl-xL/Bcl-2-associated death promoter, Bcl2 antagonist of cell death, BAD, Bbc6

检测方法:

CLIA

实验类型:

Sandwich

特异性:

Natural and recombinant mouse Bcl2-associated agonist of cell death

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cancer

规格 & 价格:

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Mouse Bad CLIA Kit

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产品说明书

说明书:

MSDS:

在线询价

数据
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序列 / 3D
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通用注释

亚单元:

Forms heterodimers with the anti-apoptotic proteins, Bcl-X(L), Bcl-2 and Bcl-W. Also binds protein S100A10 (By similarity). The Ser-112/Ser-136 phosphorylated form binds 14-3-3 proteins. Interacts with AKT1 and PIM3 (By similarity). Interacts (via BH3 domain) with NOL3 (via CARD domain); preventing the association of BAD with BCL2 (By similarity). Interacts with HIF3A isoform 2 (via C-terminus domain); the interaction reduces the binding between BAD and BAX (PubMed:21546903).

功能:

Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.

亚细胞位置:

Mitochondrion outer membrane Cytoplasm Colocalizes with HIF3A isoform 2 in the cytoplasm (PubMed:21546903). Upon phosphorylation, locates to the cytoplasm.

数据库链接

UniGene:

Mm.4387

SMR:

Q61337

STRING:

10090.ENSMUSP00000025910

KEGG:

mmu:12015

Pfam:

PF10514

Uniprot: