Rat Banf1/ Barrier-to-autointegration factor CLIA Kit

货号:

U15852r

商标:

EIAab^®

监管等级:

RUO

别名:

LAP2-binding protein 1, Baf, Bcrp1, L2bp1

检测方法:

CLIA

特异性:

Natural and recombinant rat Barrier-to-autointegration factor

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Rat Banf1 CLIA Kit

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通用注释

亚单元:

Homodimer. Heterodimerizes with BAFL. Interacts with ANKLE2/LEM4, leading to decreased phosphorylation by VRK1 and promoting dephosphorylation by protein phosphatase 2A (PP2A). Binds non-specifically to double-stranded DNA, and is found as a hexamer or dodecamer upon DNA binding. Binds to LEM domain-containing nuclear proteins such as LEMD3/MAN1, TMPO/LAP2 and EMD (emerin). Interacts with ANKLE1 (via LEM domain); the interaction may favor BANF1 dimerization. Interacts with CRX and LMNA (lamin-A). Binds linker histone H1.1 and core histones H3.

功能:

Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Contains 2 nons-pecific dsDNA-binding sites which may promote DNA cross-bridging.

亚细胞位置:

Nucleus Cytoplasm Chromosome Significantly enriched at the nuclear inner membrane, diffusely throughout the nucleus during interphase and concentrated at the chromosomes during the M-phase. The phosphorylated form (by VRK1) shows a cytoplasmic localization (By similarity).

数据库链接

UniGene:

Rn.19921

SMR:

Q9R1T1

STRING:

10116.ENSRNOP00000027734

KEGG:

rno:114087

Pfam:

PF02961

Uniprot: