Rat Bag6/ Large proline-rich protein BAG6 CLIA Kit
大号富含脯氨酸蛋白BAG6

货号:

U14404r

商标:

EIAab^®

监管等级:

RUO

别名:

BCL2-associated athanogene 6, HLA-B-associated transcript 3, Bat3

检测方法:

CLIA

特异性:

Natural and recombinant rat Large proline-rich protein BAG6

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cancer

规格 & 价格:

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Rat Bag6 CLIA Kit

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通用注释

亚单元:

Component of the BAG6/BAT3 complex, also named BAT3 complex, at least composed of BAG6, UBL4A and GET4/TRC35. Interacts with GET4; the interaction is direct and localizes BAG6 in the cytosol (By similarity). Interacts with AIFM1. Interacts with HSPA2 (By similarity). Interacts with CTCFL. Interacts with p300/EP300. Interacts (via ubiquitin-like domain) with RNF126; required for BAG6-dependent ubiquitination of proteins mislocalized to the cytosol. Interacts (via ubiquitin-like domain) with SGTA; SGTA competes with RNF126 by binding the same region of BAG6, thereby promoting deubiquitination of BAG6-target proteins and rescuing them from degradation. Interacts with ricin A chain. Interacts with VCP and AMFR; both form the VCP/p97-AMFR/gp78 complex. Interacts with SYVN1. Interacts with USP13; the interaction is direct and may mediate UBL4A deubiquitination.

功能:

May mediate ricin-induced apoptosis.

亚细胞位置:

Cytoplasm Cytosol Nucleus Secreted Exosome Normally localized in cytosol and nucleus, it can also be released extracellularly, in exosomes, by tumor and myeloid dendritic cells.

数据库链接

UniGene:

Rn.203343

SMR:

Q6MG49

STRING:

10116.ENSRNOP00000057557

KEGG:

rno:94342

Pfam:

PF12057

Uniprot: