Rat Bbc3/ Bcl-2-binding component 3 CLIA Kit
Bcl-2-bindingcomponent3

货号:

U1909r

商标:

EIAab^®

监管等级:

RUO

别名:

p53 up-regulated modulator of apoptosis, Puma

检测方法:

CLIA

特异性:

Natural and recombinant rat Bcl-2-binding component 3

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cancer

规格 & 价格:

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通用注释

亚单元:

Interacts with BCL2, BCL2L1/BCL-XL, MCL1 and BCL2A1 (By similarity). Interacts (via BH3 domain) with NOL3 (via CARD domain); preventing the association of BBC3 with BCL2 and resulting in activation of CASP8.

功能:

Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53 (By similarity). Essential for ER stress-induced cell death.

亚细胞位置:

Mitochondrion Localized to the mitochondria in order to induce cytochrome c release.

数据库链接

UniGene:

Rn.25176

SMR:

Q80ZG6

KEGG:

rno:317673

Pfam:

PF15826

Uniprot: