C5AR1 (基因名), C5a anaphylatoxin chemotactic receptor 1 (蛋白名), c5ar1_human.
产品名称:
Human C5AR1/ C5a anaphylatoxin chemotactic receptor 1 CLIA Kit
C5a过敏性毒素趋化受体
货号:
U9156h
商标:
EIAab®
监管等级:
别名:
C5a anaphylatoxin chemotactic receptor, C5a-R, CD88, C5AR, C5R1
检测方法:
CLIA
特异性:
Natural and recombinant human C5a anaphylatoxin chemotactic receptor 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Immunology
通用注释
亚单元:
Homodimer. May also form higher-order oligomers (PubMed:12835319). Interacts (when phosphorylated) with ARRB1 and ARRB2; the interaction is associated with internalization of C5aR (PubMed:12464600). Interacts (via N-terminal domain) with S.aureus chemotaxis inhibitory protein (CHIPS); the interaction blocks the receptor and may thus inhibit the immune response (PubMed:15153520, PubMed:15542591, PubMed:21706042).
功能:
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).
亚细胞位置:
Cell membrane
Multi-pass membrane protein
Cytoplasmic vesicle
Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles.
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