CD4 (基因名), T-cell surface glycoprotein CD4 (蛋白名), cd4_human.
产品名称:
Human CD4/ T-cell surface glycoprotein CD4 CLIA Kit
T细胞表面糖蛋白CD4
货号:
U1014h
商标:
EIAab®
监管等级:
别名:
T-cell surface antigen T4/Leu-3, CD4
检测方法:
CLIA
实验类型:
Sandwich
检测范围:
0.625-40ng/mL
特异性:
Natural and recombinant human T-cell surface glycoprotein CD4
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Immunology
通用注释
亚单元:
(Microbial infection) Interacts with Human Herpes virus 7 surface proteins.
功能:
(Microbial infection) Acts as a receptor for human immunodeficiency virus-1 (PubMed:2214026, PubMed:16331979, PubMed:9641677). Down-regulated by HIV-1 Vpu (PubMed:17346169). Acts as a receptor for Human Herpes virus 7/HHV-7 (PubMed:7909607).
亚细胞位置:
Cell membrane
Single-pass type I membrane protein
Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
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