Human C9/ Complement component C9 CLIA Kit
补体成分C9

货号:

U14963h

商标:

EIAab^®

监管等级:

RUO

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

39-2500pg/mL

特异性:

Natural and recombinant human Complement component C9

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Neurosciences

规格 & 价格:

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Human C9 CLIA Kit

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产品说明书

说明书:

MSDS:

在线询价

数据
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序列 / 3D
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通用注释

亚单元:

Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9 (PubMed:22832194). About 20 C9 chains oligomerize to give rise to a huge beta-barrel that forms a 100 Angstrom diameter pore in target mebranes (PubMed:26841934).

功能:

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells (PubMed:9634479, PubMed:9212048, PubMed:26841934). C9 is the pore-forming subunit of the MAC (PubMed:4055801, PubMed:26841934).

亚细胞位置:

Secreted Target cell membrane Multi-pass membrane protein Secreted as soluble monomer. Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore.

数据库链接

UniGene:

Hs.654443

SMR:

P02748

STRING:

9606.ENSP00000263408

KEGG:

hsa:735

MIM:

120940

Pfam: