Human CREB1/ Cyclic AMP-responsive element-binding protein 1 CLIA Kit
cAMP反应元件结合蛋白1

货号:

U1318h

商标:

EIAab^®

监管等级:

RUO

别名:

CREB-1

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

0.2-12.5ng/mL

特异性:

Natural and recombinant human Cyclic AMP-responsive element-binding protein 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Neurosciences

规格 & 价格:

关注

Human CREB1 CLIA Kit

邮箱 *

消息 *

Please 登录.

产品说明书

说明书:

MSDS:

在线询价

数据
文献
序列 / 3D
反馈墙 (0)

通用注释

亚单元:

Interacts with PPRC1. Binds DNA as a dimer. This dimer is stabilized by magnesium ions. Interacts, through the bZIP domain, with the coactivators TORC1/CRTC1, TORC2/CRTC2 and TORC3/CRTC3. When phosphorylated on Ser-133, binds CREBBP (By similarity). Interacts with CREBL2; regulates CREB1 phosphorylation, stability and transcriptional activity (By similarity). Interacts (phosphorylated form) with TOX3. Interacts with ARRB1. Binds to HIPK2. Interacts with SGK1.

功能:

Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

亚细胞位置:

Nucleus

数据库链接

UniGene:

Hs.516646

SMR:

P16220

STRING:

9606.ENSP00000387699

KEGG:

hsa:1385

MIM: