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DICER1 (基因名), Endoribonuclease Dicer (蛋白名), dicer_human.

产品名称:

Human DICER1/ Endoribonuclease Dicer CLIA Kit
内切核糖核酸酶Dicer

货号:

U0156h

商标:

EIAab^®

监管等级:

RUO

别名:

Helicase with RNase motif, Helicase MOI, DICER, HERNA, KIAA0928

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

39-2500pg/mL

特异性:

Natural and recombinant human Endoribonuclease Dicer

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Human DICER1 CLIA Kit

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产品说明书

说明书:

MSDS:

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通用注释

亚单元:

Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2; DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with DHX9, AGO1, PIWIL1 and PRKRA. Associates with the 60S ribosome. Interacts with BCDIN3D. Interacts with AGO2, TARBP2, EIF6, MOV10 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC) (PubMed:17507929).

功能:

Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.

亚细胞位置:

Cytoplasm

数据库链接

UniGene:

Hs.738957

SMR:

Q9UPY3

STRING:

9606.ENSP00000343745

KEGG:

hsa:23405

MIM:

138800

Pfam:

PF00270

Uniprot:

Q9UPY3

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Chicken DICER1 ELISA Kit

Mouse Dicer1 CLIA Kit

Bovine DICER1 CLIA Kit

序列长度:

1922

序列:

仅供参考，详细请咨询（services@eiaab.com）

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KSAAARRALR | SLKANQPQVP | NS

3D 模型:

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Human DICER1/ Endoribonuclease Dicer CLIA Kit 内切核糖核酸酶Dicer

U0156h

Helicase with RNase motif, Helicase MOI, DICER, HERNA, KIAA0928

Human DICER1/ Endoribonuclease Dicer CLIA Kit
内切核糖核酸酶Dicer