Hadha (基因名), Trifunctional enzyme subunit alpha, mitochondrial (蛋白名), echa_mouse.
产品名称:
Mouse Hadha/ Trifunctional enzyme subunit alpha, mitochondrial CLIA Kit
线粒体三功能酶亚基α
货号:
U14271m
商标:
EIAab®
监管等级:
别名:
Monolysocardiolipin acyltransferase, TP-alpha
检测方法:
CLIA
特异性:
Natural and recombinant mouse Trifunctional enzyme subunit alpha, mitochondrial
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cardiovascular
通用注释
亚单元:
Heterotetramer of 2 alpha/HADHA and 2 beta/HADHB subunits; forms the mitochondrial trifunctional enzyme. Also purified as higher order heterooligomers including a 4 alpha/HADHA and 4 beta/HADHB heterooligomer which physiological significance remains unclear.
功能:
Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA described here carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities while the trifunctional enzyme subunit beta/HADHB bears the 3-ketoacyl-CoA thiolase activity. Independently of the subunit beta, the trifunctional enzyme subunit alpha/HADHA also has a monolysocardiolipin acyltransferase activity. It acylates monolysocardiolipin into cardiolipin, a major mitochondrial membrane phospholipid which plays a key role in apoptosis and supports mitochondrial respiratory chain complexes in the generation of ATP. Allows the acylation of monolysocardiolipin with different acyl-CoA substrates including oleoyl-CoA for which it displays the highest activity.
亚细胞位置:
Mitochondrion
Mitochondrion inner membrane
Protein stability and association with mitochondrion inner membrane do not require HADHB.
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