Apela (基因名), Apelin receptor early endogenous ligand (蛋白名), ela_rat.
产品名称:
Rat Apela/ Apelin receptor early endogenous ligand CLIA Kit
Apelin受体早期内源性配体
货号:
U15451r
商标:
EIAab®
监管等级:
别名:
Protein Elabela, Protein Toddler, ELA, Ela, Tdl
检测方法:
CLIA
特异性:
Natural and recombinant rat Apelin receptor early endogenous ligand
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Interacts with APLNR.
功能:
Endogenous ligand for the apelin receptor (APLNR) (PubMed:28137936). Hormone required for mesendodermal differentiation, blood vessels formation and heart morphogenesis during early development and for adult cardiovascular homeostasis (PubMed:26611206, PubMed:28137936). Drives internalization of APLNR. Acts as a motogen by promoting mesendodermal cell migration during gastrulation by binding and activating APLNR. Acts as an early embryonic regulator of cellular movement with a role in migration and development of cardiac progenitor cells. May act as a chemoattractant for the activation of angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis. Positively regulates sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel sprouting. Plays a role in placental vascular development; promotes placental trophoblast invasion and spiral artery remodeling in the uterus (By similarity). Involved in the regulation of maternal cardiovascular homeostasis to prevent gestational hypertension and for potent cardioprotective functions during heart failure (PubMed:26611206). Mediates myocardial contractility in an ERK1/2-dependent manner (PubMed:26611206).
亚细胞位置:
Secreted
Secreted
Extracellular space
Found in blood plasma. Found in serum of pregnant mice, peaking at midgestation; indicating a maternal and zygotic origin of circulating APELA during pregnancy.
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