Rat Erbb2/ Receptor tyrosine-protein kinase erbB-2 CLIA Kit
受体酪氨酸蛋白激酶erbB-2

货号:

U1867r

商标:

EIAab^®

监管等级:

RUO

别名:

Epidermal growth factor receptor-related protein, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, p185erbB2, p185neu, CD340, Neu

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

39-2500pg/mL

特异性:

Natural and recombinant rat Receptor tyrosine-protein kinase erbB-2

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cancer

规格 & 价格:

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Rat Erbb2 CLIA Kit

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
序列 / 3D
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通用注释

亚单元:

Homodimer. Heterodimer with EGFR, ERBB3 and ERBB4. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1198. Interacts with PRKCABP and PLXNB1. Interacts (when phosphorylated on Tyr-1250) with MEMO1. Interacts with MUC1. Interacts (when phosphorylated on Tyr-1141) with GRB7 (via SH2 domain). Interacts (when phosphorylated on Tyr-1250) with ERBIN Interacts with SRC, KPNB1, RANBP2, EEA1, CRM1, CLTC, PTK6, RPA194, MYOC and ACTB. Interacts with HSP90AA1 and HSP90AB1; the interaction suppresses ERBB2 kinase activity.

功能:

In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.

亚细胞位置:

Cell membrane Single-pass type I membrane protein Cytoplasm Perinuclear region Nucleus

数据库链接

UniGene:

Rn.93966

SMR:

P06494

STRING:

10116.ENSRNOP00000040591

Pfam:

PF00757

Uniprot: