FAM83B (基因名), Protein FAM83B (蛋白名), fa83b_human.
通用注释
亚单元:
Interacts with EGFR; the interaction is disrupted by EGF stimulation (PubMed:23912460). Interacts with RAF1; displaces 14-3-3 proteins from RAF1 and activates RAF1 within the RAS/MAPK signaling cascade (PubMed:22886302). Interacts with AKT1, PIK3CA and PIK3R1; activates the PI3K/AKT signaling cascade (PubMed:23676467).
功能:
Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. May activate both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades.
亚细胞位置:
Cytoplasm
Membrane
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
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