FABP5 (基因名), Fatty acid-binding protein 5 (蛋白名), fabp5_human.
产品名称:
Human FABP5/ Fatty acid-binding protein 5 CLIA Kit
表皮脂肪酸结合蛋白
货号:
U0344h
商标:
EIAab®
监管等级:
别名:
Epidermal-type fatty acid-binding protein, Fatty acid-binding protein, epidermal, Psoriasis-associated fatty acid-binding protein homolog, E-FABP, PA-FABP
检测方法:
CLIA
特异性:
Natural and recombinant human Fatty acid-binding protein 5
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
登录.
研究领域:
Cardiovascular
通用注释
亚单元:
Monomer. Homodimer.
功能:
Intracellular carrier for long-chain fatty acids and related active lipids, such as the endocannabinoid, that regulates the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (PubMed:22170058). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity). May be involved in keratinocyte differentiation (PubMed:8092987).
亚细胞位置:
Cytoplasm
Nucleus
Cell junction
Synapse
Cell junction
Synapse
Postsynaptic cell membrane
Postsynaptic density
Secreted
Localizes primarily to the cytoplasm. Upon certain ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into nucleus (PubMed:24692551). Secreted by astrocytes, but not by neurons (By similarity).
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