Mouse Fads1/ Acyl-CoA (8-3)-desaturase CLIA Kit
脂肪酸去饱和酶1

货号:

U0671m

商标:

EIAab^®

监管等级:

RUO

别名:

Delta(5) fatty acid desaturase, Fatty acid desaturase 1, D5D

检测方法:

CLIA

特异性:

Natural and recombinant mouse Acyl-CoA (8-3)-desaturase

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Mouse Fads1 CLIA Kit

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通用注释

亚单元:

N/A

功能:

Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Specifically, desaturates dihomo-gamma-linoleoate (DGLA) (20:3n-6) and eicosatetraenoate (ETA) (20:4n-3) to generate arachidonate (AA) (20:4n-6) and eicosapentaenoate (EPA) (20:5n-3), respectively (Probable). As a rate limiting enzyme for DGLA (20:3n-6) and AA (20:4n-6)-derived eicosanoid biosynthesis, controls the metabolism of inflammatory lipids like prostaglandin E2, critical for efficient acute inflammatory response and maintenance of epithelium homeostasis. Contributes to membrane phospholipid biosynthesis by providing AA (20:4n-6) as a major acyl chain esterified into phospholipids. In particular, regulates phosphatidylinositol-4,5-bisphosphate levels, modulating inflammatory cytokine production in T-cells (PubMed:22534642). Also desaturates (11E)-octadecenoate (trans-vaccenoate)(18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6) (By similarity).

亚细胞位置:

Endoplasmic reticulum membrane Multi-pass membrane protein Mitochondrion

数据库链接

UniGene:

Mm.30158

SMR:

Q920L1

STRING:

10090.ENSMUSP00000010807

KEGG:

mmu:76267

Pfam: