FANCM (基因名), Fanconi anemia group M protein (蛋白名), fancm_chick.
产品名称:
Chicken FANCM/ Fanconi anemia group M protein CLIA Kit
货号:
U14596c
商标:
EIAab®
监管等级:
别名:
ATP-dependent RNA helicase FANCM, Fanconi anemia-associated polypeptide of 250 kDa, Protein Hef ortholog, FAAP250, Protein FACM
检测方法:
CLIA
特异性:
Natural and recombinant chicken Fanconi anemia group M protein
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Component of the Fanconi anemia (FA) core complex. The FA core complex associates with Bloom syndrome (BLM) complex. This supercomplex between FA and BLM complexes has been called BRAFT.
功能:
DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (By similarity). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116434, PubMed:19465393). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (By similarity). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork (By similarity). This activity is strongly stimulated in the presence of CENPS and CENPX (By similarity). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (By similarity). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA.
亚细胞位置:
Nucleus
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