Human FBLN5/ Fibulin-5 CLIA Kit
HumanFIBL-5

货号:

U0209h

商标:

EIAab^®

监管等级:

RUO

别名:

Developmental arteries and neural crest EGF-like protein, Urine p50 protein, Dance, UP50, UNQ184/PRO210, FIBL-5, DANCE

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

0.2-12.5ng/mL

特异性:

Natural and recombinant human Fibulin-5

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Signal Transduction

规格 & 价格:

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Human FBLN5 CLIA Kit

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
序列 / 3D
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通用注释

亚单元:

Homodimer (PubMed:20007835). Monomer (PubMed:15790312, PubMed:19617354), homodimerizes in presence of Ca(2+) (PubMed:19617354). Interacts with ELN (PubMed:17035250, PubMed:15790312). Interacts (via N-terminus) with the integrins ITGAV/ITGB3, ITGAV/ITGB5 and ITGA9/ITGB1 (By similarity). Interacts with FBN1 (via N-terminal domain). Forms a ternary complex with ELN and FBN1 (PubMed:17255108).

功能:

Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN (PubMed:18185537). Stabilizes and organizes elastic fibers in the skin, lung and vasculature (By similarity). Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling (PubMed:10428823). May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108).

亚细胞位置:

Secreted Secreted Extracellular space Extracellular matrix co-localizes with ELN in elastic fibers.

数据库链接

UniGene:

Hs.332708

SMR:

Q9UBX5

STRING:

9606.ENSP00000345008

KEGG:

hsa:10516

MIM: