FCN1 (基因名), Ficolin-1 (蛋白名), fcn1_pig.
通用注释
亚单元:
Homotrimer. Interacts with elastin/ELN. Interacts (via Fibrinogen C-terminal domain) with FFAR2. Interacts with CRP; may regulate monocyte activation by FCN1.
功能:
Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8. Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage.
亚细胞位置:
Secreted
Cell membrane
Peripheral membrane protein
Extracellular side
Found on the monocyte and granulocyte surface.
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
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