FEN1 (基因名), Flap endonuclease 1 (蛋白名), fen1_chick.
产品名称:
Chicken FEN1/ Flap endonuclease 1 CLIA Kit
皮瓣核酸内切酶1
货号:
U15243c
商标:
EIAab®
监管等级:
别名:
Flap structure-specific endonuclease 1, RCJMB04_5g12, FEN-1
检测方法:
CLIA
特异性:
Natural and recombinant chicken Flap endonuclease 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.
功能:
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
亚细胞位置:
Nucleus
Nucleolus
Nucleus
Nucleoplasm
Mitochondrion
Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
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