FER (基因名), Tyrosine-protein kinase Fer (蛋白名), fer_canfa.
产品名称:
Dog FER/ Tyrosine-protein kinase Fer CLIA Kit
货号:
-
商标:
EIAab®
监管等级:
别名:
Proto-oncogene c-Fer, p94-Fer
检测方法:
CLIA
特异性:
Natural and recombinant dog Tyrosine-protein kinase Fer
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cancer
通用注释
亚单元:
Homotrimer. Interacts with CTNND1, EGFR, FLT3, IRS1, PECAM1, PIK3R1 and PDGFR. Interacts (via SH2 domain) with CTTN. Component of a complex that contains at least FER, CTTN and PTK2/FAK.
功能:
Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell attachment and cell migration. Acts downstream of EGF, PDGFA and PDGFB receptors. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Phosphorylates CTTN, CTNND1, PTK2/FAK, GAB1, PECAM1 and PTPN11.
亚细胞位置:
Cytoplasm
Cytoplasm
cytoskeleton
Cell membrane
Peripheral membrane protein
Cytoplasmic side
Cell projection
Cell junction
Membrane
Peripheral membrane protein
Cytoplasmic side
Nucleus
Cytoplasm
cell cortex
Associated with the chromatin. Detected on microtubles in polarized and motile vascular endothelial cells. Colocalizes with F-actin at the cell cortex. Colocalizes with PECAM1 and CTNND1 at nascent cell-cell contacts.
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