FGFR1 (基因名), Fibroblast growth factor receptor 1 (蛋白名), fgfr1_chick.
产品名称:
Chicken FGFR1/ Fibroblast growth factor receptor 1 CLIA Kit
成纤维生长因子受体1
货号:
U0074c
商标:
EIAab®
监管等级:
别名:
Basic fibroblast growth factor receptor 1, Tyrosine kinase receptor CEK1, FGFR-1, CEK1
检测方法:
CLIA
特异性:
Natural and recombinant chicken Fibroblast growth factor receptor 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Monomer. Homodimer after ligand binding.
功能:
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by ubiquitination, internalization and degradation.
亚细胞位置:
Cell membrane
Single-pass type I membrane protein
Nucleus
Cytoplasm
Cytosol
Cytoplasmic vesicle
After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus (By similarity).
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