Human FOXO3/ Forkhead box protein O3 CLIA Kit
叉头框蛋白O3

货号:

U0762h

商标:

EIAab^®

监管等级:

RUO

别名:

AF6q21 protein, Forkhead in rhabdomyosarcoma-like 1, FKHRL1, FOXO3A

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

39-2500pg/mL

特异性:

Natural and recombinant human Forkhead box protein O3

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cancer

规格 & 价格:

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Human FOXO3 CLIA Kit

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产品说明书

说明书:

MSDS:

在线询价

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序列 / 3D
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通用注释

亚单元:

Interacts with SIRT2; the interaction occurs independently of SIRT2 deacetylase activity (By similarity). Interacts with YWHAB/14-3-3-beta and YWHAZ/14-3-3-zeta, which are required for cytosolic sequestration (PubMed:16751106). Upon oxidative stress, interacts with STK4/MST1, which disrupts interaction with YWHAB/14-3-3-beta and leads to nuclear translocation (PubMed:16751106). Interacts with PIM1 (PubMed:18593906). Interacts with DDIT3/CHOP (PubMed:22761832). Interacts (deacetylated form) with SKP2 (PubMed:21841822). Interacts with CHUK and IKBKB (PubMed:15084260, PubMed:22313691). Interacts with CAMK2A, CAMK2B and calcineurin A.

功能:

Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.

亚细胞位置:

Cytoplasm Cytosol Nucleus Retention in the cytoplasm contributes to its inactivation. Translocates to the nucleus upon oxidative stress and in the absence of survival factors.

数据库链接

UniGene:

Hs.220950

SMR:

O43524

STRING:

9606.ENSP00000339527

KEGG:

hsa:2309

MIM:

602681

Pfam: