FZD6 (基因名), Frizzled-6 (蛋白名), fzd6_canlf.
通用注释
亚单元:
N/A
功能:
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear.
亚细胞位置:
Membrane
Multi-pass membrane protein
Cell membrane
Multi-pass membrane protein
Cell surface
Apical cell membrane
Multi-pass membrane protein
Cytoplasmic vesicle membrane
Multi-pass membrane protein
Colocalizes with FZD3 at the apical face of cells (By similarity).
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