Pig H3F3A/ Histone H3.3 CLIA Kit
组蛋白H3.3

货号:

U5810p

商标:

EIAab^®

监管等级:

RUO

别名:

H3.3A

检测方法:

CLIA

特异性:

Natural and recombinant pig Histone H3.3

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Pig H3F3A CLIA Kit

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产品说明书

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数据
文献
序列 / 3D
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通用注释

亚单元:

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with HIRA, a chaperone required for its incorporation into nucleosomes. Interacts with ZMYND11; when trimethylated at 'Lys-36' (H3.3K36me3).

功能:

Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

亚细胞位置:

Nucleus Chromosome

数据库链接

UniGene:

Ssc.53883

SMR:

Q71LE2

STRING:

9823.ENSSSCP00000026784

KEGG:

ssc:100521680

Pfam: