首页 > 化学发光试剂盒 > Human CD74 CLIA Kit

CD74 (基因名), HLA class II histocompatibility antigen gamma chain (蛋白名), hg2a_human.

产品名称:

Human CD74/ HLA class II histocompatibility antigen gamma chain CLIA Kit
HLAII型组织适合性抗原γ链

货号:

U13627h

商标:

EIAab^®

监管等级:

RUO

别名:

HLA-DR antigens-associated invariant chain, Ia antigen-associated invariant chain, p33, Ii, CD74, DHLAG

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

0.078-5ng/mL

特异性:

Natural and recombinant human HLA class II histocompatibility antigen gamma chain

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cancer

规格 & 价格:

关注

Human CD74 CLIA Kit

邮箱 *

消息 *

Please 登录.

产品说明书

说明书:

MSDS:

在线询价

数据
文献
序列 / 3D
反馈墙 (0)

通用注释

亚单元:

Homotrimer. In the endoplasmic reticulum (ER) it forms a heterononameric MHC II-Ii complex: 3 MHC class II molecules (heterodimers of an alpha and a beta subunit) bind to the CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system, the CD74 component undergoes sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide) attached to the MHC class II molecule (alpha-beta-CLIP complex). This processed complex interacts with HLA_DM and HLA_DO heterodimers in order to release CLIP and facilitate the binding of antigenic peptides to the MHC class II molecules. Interacts with CD44; this complex is essential for the MIF-induced signaling cascade that results in B cell survival.

功能:

Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.

亚细胞位置:

Cell membrane Single-pass type II membrane protein Endoplasmic reticulum membrane Golgi apparatus Trans-Golgi network Endosome Lysosome Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.

数据库链接

UniGene:

Hs.436568

SMR:

P04233

STRING:

9606.ENSP00000009530

KEGG:

hsa:972

MIM:

142790

Pfam: