Chicken HMCES/ Abasic site processing protein HMCES CLIA Kit
胚胎干细胞特异性5-羟甲基胞嘧啶结合蛋白

货号:

U15335c

商标:

EIAab^®

监管等级:

RUO

别名:

Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein, Peptidase HMCES, Putative endonuclease HMCES, SRAP domain-containing protein 1, ES cell-specific 5hmC-binding protein, RCJMB04_15p13, SRAPD1

检测方法:

CLIA

特异性:

Natural and recombinant chicken Abasic site processing protein HMCES

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

关注

Chicken HMCES CLIA Kit

邮箱 *

消息 *

Please 登录.

产品说明书

在线询价

数据
文献
序列 / 3D
反馈墙 (0)

通用注释

亚单元:

N/A

功能:

Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks (By similarity). Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells. May act as an endonuclease that specifically cleaves 5hmC-containing DNA; additional experiments are however required to confirm this activity in vivo (By similarity).

亚细胞位置:

Chromosome Recruited to chromatin following DNA damage. Localizes to replication forks.

数据库链接

UniGene:

Gga.1246

SMR:

Q5ZJT1

STRING:

9031.ENSGALP00000009476

KEGG:

gga:416015

Pfam: