Chicken HMGB1/ High mobility group protein B1 CLIA Kit
高迁移率族蛋白B1

货号:

U0399c

商标:

EIAab^®

监管等级:

RUO

别名:

High mobility group protein 1, HMG-1, RCJMB04_15a21, HMG1

检测方法:

CLIA

特异性:

Natural and recombinant chicken High mobility group protein B1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Epigenetics

规格 & 价格:

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Chicken HMGB1 CLIA Kit

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通用注释

亚单元:

N/A

功能:

Multifunctional redox sensitive protein with various roles in different cellular compartments. Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Can restructure the canonical nucleosome. Proposed to be an universal biosensor for nucleic acids. May promote inflammatory response to sterile and infectious signals and may be involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm may function as sensor and/or chaperone for immunogenic nucleic acids, and mediate autophagy. May act as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury.

亚细胞位置:

Nucleus Chromosome Cytoplasm Secreted

数据库链接

UniGene:

Gga.4638

SMR:

Q9YH06

STRING:

9031.ENSGALP00000027541

KEGG:

gga:395724

Pfam: