EBI3 (基因名), Interleukin-27 subunit beta (蛋白名), il27b_human.
产品名称:
Human EBI3/ Interleukin-27 subunit beta CLIA Kit
白细胞介素-27β亚基
货号:
U9188h
商标:
EIAab®
监管等级:
别名:
Epstein-Barr virus-induced gene 3 protein, EBV-induced gene 3 protein, IL-27 subunit beta, IL27B
检测方法:
CLIA
实验类型:
Sandwich
检测范围:
3.9-250pg/mL
特异性:
Natural and recombinant human Interleukin-27 subunit beta
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Heterodimer with IL27/IL27A; not disulfide-linked. This heterodimer is known as interleukin IL-27. EBI3 is also a component of the IL-12 heterodimer. Interacts with SQSTM1. Heterodimer with IL12A; this heterodimer is known as interleukin IL-35.
功能:
Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.
亚细胞位置:
Secreted
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