Jade1 (基因名), Protein Jade-1 (蛋白名), jade1_mouse.
产品名称:
Mouse Jade1/ Protein Jade-1 CLIA Kit
货号:
-
商标:
EIAab®
监管等级:
别名:
Jade family PHD finger protein 1, PHD finger protein 17, Kiaa1807, Phf17
检测方法:
CLIA
特异性:
Natural and recombinant mouse Protein Jade-1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cancer
通用注释
亚单元:
Component of the HBO1 complex composed at least of ING4 or ING5, MYST2/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Isoform 2 interacts with VHL and KAT5. Interacts with NPHP4.
功能:
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function.
亚细胞位置:
Cytoplasm
Nucleus
Cytoplasm
Cytoskeleton
Cilium basal body
Localizes to the ciliary transition zone.
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
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