Jade2 (基因名), E3 ubiquitin-protein ligase Jade-2 (蛋白名), jade2_mouse.
产品名称:
Mouse Jade2/ E3 ubiquitin-protein ligase Jade-2 CLIA Kit
货号:
-
商标:
EIAab®
监管等级:
别名:
Jade family PHD finger protein 2, PHD finger protein 15, Kiaa0239, Phf15
检测方法:
CLIA
特异性:
Natural and recombinant mouse E3 ubiquitin-protein ligase Jade-2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Component of the HBO1 complex composed at least of ING4 or ING5, MYST2/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3 (By similarity). Interacts (via C-terminus) with KDM1A (via AOD/Tower domain) (PubMed:25018020).
功能:
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo (By similarity). Acts as a E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A. Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis (PubMed:25018020).
亚细胞位置:
N/A
数据库链接
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