Jagn1 (基因名), Protein jagunal homolog 1 (蛋白名), jagn1_rat.
通用注释
亚单元:
Interacts with COPA, COPB2 and COPG2.
功能:
Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contributing to the viability and migration of neutrophils.
亚细胞位置:
Endoplasmic reticulum membrane
Multi-pass membrane protein
数据库链接
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