Josd1 (基因名), Josephin-1 (蛋白名), jos1_mouse.
通用注释
亚单元:
Interacts with beta-actin/ACTB.
功能:
Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity.
亚细胞位置:
Cell membrane
Cytoplasm
Ubiquitination increases localization the plasma membrane. In the cytosol, the unubiquitinated form may be associated with the cytoskeleton via ACTB-binding.
数据库链接
UniGene:
STRING:
KEGG:
Pfam:
Uniprot:
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