KRT17 (基因名), Keratin, type I cytoskeletal 17 (蛋白名), k1c17_bovin.
产品名称:
Bovine KRT17/ Keratin, type I cytoskeletal 17 CLIA Kit
角蛋白,I型细胞骨架
货号:
U1822b
商标:
EIAab®
监管等级:
别名:
Cytokeratin-17, Keratin-17, CK-17, K17
检测方法:
CLIA
特异性:
Natural and recombinant bovine Keratin, type I cytoskeletal 17
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Heterodimer of a type I and a type II keratin. KRT17 associates with KRT6 isomers (KRT6A or KRT6B). Interacts with TRADD and SFN.
功能:
Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
亚细胞位置:
Cytoplasm
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
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