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MKI67 (基因名), Proliferation marker protein Ki-67 (蛋白名), ki67_human.

产品名称:

Human MKI67/ Proliferation marker protein Ki-67 CLIA Kit
抗原KI-67

货号:

U2047h

商标:

EIAab^®

监管等级:

RUO

别名:

Antigen identified by monoclonal antibody Ki-67, Antigen KI-67

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

39-2500pg/mL

特异性:

Natural and recombinant human Proliferation marker protein Ki-67

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Epigenetics

规格 & 价格:

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产品说明书

说明书:

MSDS:

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通用注释

亚单元:

Interacts with KIF15 (PubMed:10878014). Interacts (via the FHA domain) with NIFK (PubMed:11342549, PubMed:14659764, PubMed:16244663). Interacts with PPP1CC (PubMed:24867636). Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity (PubMed:19131338, PubMed:23178126).

功能:

Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed.

亚细胞位置:

Chromosome Nucleus Nucleus Nucleolus Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the mitotic chromosome surface (PubMed:27362226). Associates with satellite DNA in G1 phase (PubMed:9510506). Binds tightly to chromatin in interphase, chromatin-binding decreases in mitosis when it associates with the surface of the condensed chromosomes (PubMed:15896774, PubMed:22002106). Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix (PubMed:22002106).

数据库链接

UniGene:

Hs.689823

SMR:

P46013

STRING:

9606.ENSP00000357643

KEGG:

hsa:4288

MIM:

176741

Pfam:

PF00498

Uniprot:

P46013

相关产品

Human MKI67 ELISA Kit

Human MKI67 Protein

序列长度:

3256

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Human MKI67/ Proliferation marker protein Ki-67 CLIA Kit 抗原KI-67

U2047h

Antigen identified by monoclonal antibody Ki-67, Antigen KI-67

Human MKI67/ Proliferation marker protein Ki-67 CLIA Kit
抗原KI-67