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LAIR1 (基因名), Leukocyte-associated immunoglobulin-like receptor 1 (蛋白名), lair1_human.

产品名称:

Human LAIR1/ Leukocyte-associated immunoglobulin-like receptor 1 CLIA Kit
白细胞相关免疫球蛋白样受体1

货号:

U9027h

商标:

EIAab^®

监管等级:

RUO

别名:

CD305, LAIR-1, CD305

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

19.5-2500pg/mL

特异性:

Natural and recombinant human Leukocyte-associated immunoglobulin-like receptor 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Immunology

规格 & 价格:

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产品说明书

说明书:

MSDS:

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通用注释

亚单元:

Interacts with SH2 domains of tyrosine-protein phosphatases PTPN6 and PTPN11. The interaction with PTPN6 is constitutive. Interacts with the SH2 domain of CSK. Binds with high affinity to extracellular matrix collagens, the interaction is functionally important.

功能:

Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.

亚细胞位置:

Cell membrane Single-pass type I membrane protein

数据库链接

UniGene:

Hs.572535

SMR:

Q6GTX8

STRING:

9606.ENSP00000375622

KEGG:

hsa:3903

MIM: