Mouse Lats2/ Serine/threonine-protein kinase LATS2 CLIA Kit
丝氨酸/苏氨酸蛋白激酶LATS2

货号:

U14088m

商标:

EIAab^®

监管等级:

RUO

别名:

Kinase phosphorylated during mitosis protein, Large tumor suppressor homolog 2, Serine/threonine-protein kinase kpm

检测方法:

CLIA

特异性:

Natural and recombinant mouse Serine/threonine-protein kinase LATS2

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Mouse Lats2 CLIA Kit

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亚单元:

Interacts with and is phosphorylated by AURKA. Binds to AR (By similarity). Interacts with AJUBA during mitosis and this complex regulates organization of the spindle apparatus through recruitment of gamma-tubulin to the centrosome. Interacts (via PPxY motif) with YAP1 (via WW domains). Interacts with MOB1A and MOB1B (By similarity). Interacts with LIMD1, WTIP and AJUBA (By similarity). Interacts with SNAI1.

功能:

Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ.

亚细胞位置:

Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Cytoplasm Cytoplasm Cytoskeleton Spindle pole Nucleus Colocalizes with AURKA at the centrosomes during interphase, early prophase and cytokinesis (By similarity). Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis. Translocates to the nucleus upon mitotic stress by nocodazole treatment (By similarity).

数据库链接

UniGene:

Mm.347899

SMR:

Q7TSJ6

STRING:

10090.ENSMUSP00000022531

KEGG:

mmu:50523

Pfam:

PF00069

Uniprot: