Rat Lcat/ Phosphatidylcholine-sterol acyltransferase CLIA Kit
Phosphatidylcholine-sterol酰基转移酶

货号:

U2114r

商标:

EIAab^®

监管等级:

RUO

别名:

Lecithin-cholesterol acyltransferase, Phospholipid-cholesterol acyltransferase

检测方法:

CLIA

特异性:

Natural and recombinant rat Phosphatidylcholine-sterol acyltransferase

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cardiovascular

规格 & 价格:

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通用注释

亚单元:

N/A

功能:

Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (By similarity). Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107, PubMed:14636062).

亚细胞位置:

Secreted Secreted into blood plasma (PubMed:8820107). Produced in astrocytes and secreted into cerebral spinal fluid (CSF) (By similarity).

数据库链接

UniGene:

Rn.10481

SMR:

P18424

STRING:

10116.ENSRNOP00000026583

Pfam:

PF02450

Uniprot: