LDLR (基因名), Low-density lipoprotein receptor (蛋白名), ldlr_pig.
产品名称:
Pig LDLR/ Low-density lipoprotein receptor CLIA Kit
低密度脂蛋白受体
货号:
U1008p
商标:
EIAab®
监管等级:
别名:
LDL receptor
检测方法:
CLIA
特异性:
Natural and recombinant pig Low-density lipoprotein receptor
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif. Interacts (via NPXY motif) with LDLRAP1 (via PID domain). Interacts with ARRB1. Interacts with SNX17. Interacts with the full length immature form of PCSK9 (via C-terminus).
功能:
Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.
亚细胞位置:
Cell membrane
Single-pass type I membrane protein
Membrane
Clathrin-coated pit
Golgi apparatus
Early endosome
Late endosome
Lysosome
Rapidly endocytosed upon ligand binding.
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