LGR4 (基因名), Leucine-rich repeat-containing G-protein coupled receptor 4 (蛋白名), lgr4_human.
产品名称:
Human LGR4/ Leucine-rich repeat-containing G-protein coupled receptor 4 CLIA Kit
富亮氨酸重复含g蛋白偶联受体4
货号:
U1155h
商标:
EIAab®
监管等级:
别名:
G-protein coupled receptor 48, GPR48
检测方法:
CLIA
实验类型:
Sandwich
检测范围:
78-5000pg/mL
特异性:
Natural and recombinant human Leucine-rich repeat-containing G-protein coupled receptor 4
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
N/A
功能:
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and proinflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP.
亚细胞位置:
Cell membrane
Multi-pass membrane protein
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