LMCD1 (基因名), LIM and cysteine-rich domains protein 1 (蛋白名), lmcd1_pig.
通用注释
亚单元:
Interacts with beta-dystroglycan. Interacts with GATA1, GATA4 and GATA6.
功能:
Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter. Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.
亚细胞位置:
Cytoplasm
Nucleus
May shuttle between the cytoplasm and the nucleus.
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
验证序列:
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