Pig LMNA/ Prelamin-A/C CLIA Kit
Prelamin-A/C

货号:

U11923p

商标:

EIAab^®

监管等级:

RUO

检测方法:

CLIA

特异性:

Natural and recombinant pig Prelamin-A/C

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cancer

规格 & 价格:

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产品说明书

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通用注释

亚单元:

Homodimer of lamin A and lamin C. Interacts with lamin-associated polypeptides IA, IB and TMPO-alpha, RB1 and with emerin. Interacts with SREBF1, SREBF2, SUN1, SUN2 and TMEM43. Interacts with TMEM201. Proteolytically processed isoform A interacts with NARF. Prelamin-A/C interacts with EMD. Interacts with MLIP; may regulate MLIP localization to the nucleus envelope. Interacts with DMPK; may regulate nuclear envelope stability Interacts with SUV39H1; the interaction increases stability of SUV39H1.

功能:

Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.

亚细胞位置:

Nucleus Nucleus envelope Nucleus lamina Nucleus Nucleoplasm Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleaveage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin-A/C, which can then be inserted into the nuclear lamina. EMD is required for proper localization of non-farnesylated prelamin-A/C (By similarity).

数据库链接

UniGene:

Ssc.944

SMR:

Q3ZD69

STRING:

9823.ENSSSCP00000006923

Pfam:

PF00038

Uniprot:

Q3ZD69

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