Chicken LIN28A/ Protein lin-28 homolog A CLIA Kit
lin-28同源蛋白

货号:

U1540c

商标:

EIAab^®

监管等级:

RUO

别名:

Lin-28A, LIN28

检测方法:

CLIA

特异性:

Natural and recombinant chicken Protein lin-28 homolog A

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Chicken LIN28A CLIA Kit

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通用注释

亚单元:

Monomer.

功能:

RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism. Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (By similarity). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Suppressor of microRNA (miRNA) biogenesis, including that of let-7. Binds specific target miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in their terminal loop, and recruits uridylyltransferase. This results in the terminal uridylation of target pre-miRNAs. Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation (By similarity). Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins. Binds to and enhances the translation of mRNAs for several metabolic enzymes, increasing glycolysis and oxidative phosphorylation. Which, with the let-7 repression may enhance tissue repair in adult tissue.

亚细胞位置:

Cytoplasm Rough endoplasmic reticulum Nucleus Nucleolus

数据库链接

UniGene:

Gga.21004

SMR:

Q45KJ5

STRING:

9031.ENSGALP00000000528

KEGG:

gga:428206

Pfam: