Rat Mafb/ Transcription factor MafB CLIA Kit

货号:

U14324r

商标:

EIAab^®

监管等级:

RUO

别名:

Transcription factor Maf-1, V-maf musculoaponeurotic fibrosarcoma oncogene homolog B, Maf-B, Maf1

检测方法:

CLIA

特异性:

Natural and recombinant rat Transcription factor MafB

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

关注

Rat Mafb CLIA Kit

邮箱 *

消息 *

Please 登录.

产品说明书

在线询价

数据
文献
序列 / 3D
反馈墙 (0)

通用注释

亚单元:

Homodimer or heterodimer with other bHLH-Zip transcription factors. Forms homodimers and heterodimers with FOS, FOSB and FOSL2, but not with JUN proteins (JUN, JUNB and JUND). Binds DNA as a homodimer or a heterodimer. Interacts with the intracellular cytoplasmic domain of LRP1 (LRPICD); the interaction results in a moderate reduction of MAFB transcriptional potential. Interacts with PAX6; the interaction is direct. Interacts with ETS1 and LRP1.

功能:

Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter. Involved either as an oncogene or as a tumor suppressor, depending on the cell context.

亚细胞位置:

Nucleus

数据库链接

UniGene:

Rn.10725

SMR:

P54842

STRING:

10116.ENSRNOP00000021452

KEGG:

rno:54264

Pfam: