Rat Mag/ Myelin-associated glycoprotein CLIA Kit
髓磷脂相关糖蛋白

货号:

U0422r

商标:

EIAab^®

监管等级:

RUO

别名:

1B236, Brain neuron cytoplasmic protein 3, Sialic acid-binding Ig-like lectin 4a, Siglec-4a

检测方法:

CLIA

特异性:

Natural and recombinant rat Myelin-associated glycoprotein

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Rat Mag CLIA Kit

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通用注释

亚单元:

Monomer and homodimer (By similarity). Interacts (via the first three N-terminal Ig-like domains) with RTN4R and RTN4RL2 (PubMed:19420245).

功能:

Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (PubMed:8995428, PubMed:9298990). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides (PubMed:17640868). In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides (PubMed:17640868). In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides (PubMed:19367338). Inhibits axon longitudinal growth (PubMed:9298990). Inhibits axon outgrowth by binding to RTN4R (By similarity). Preferentially binds to alpha-2,3-linked sialic acid (PubMed:8995428). Binds ganglioside Gt1b (PubMed:8995428).

亚细胞位置:

Cell membrane Single-pass type I membrane protein Membrane raft

数据库链接

UniGene:

Rn.87331

SMR:

P07722

STRING:

10116.ENSRNOP00000028544

KEGG:

rno:29409

Pfam: